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Durante el verano del 2022 y 2023 ocurrió la mayor epidemia de Chikungunya en Paraguay, y una de las más grandes reportadas en la región. Estuvo centralizada en el área metropolitana de Asunción en una primera etapa, pero se expandió al resto del país durante los primeros meses del 2023. Este trabajo tiene el objetivo de describir epidemiológica y clínicamente la epidemia desde su inicio en la semana epidemiológica 40 del 2022 hasta la semana 20 del 2023. Metodología: es un estudio descriptivo que utiliza los datos públicos disponibles en la página de la Dirección General de Vigilancia de la Salud. Fueron confirmados 86.761 casos, 58% femenino, 8227 ingresos hospitalarios y 248 fallecidos. La letalidad global es de 2.8 por mil casos confirmados. Los grupos etarios más afectados corresponden a la franja de 0 a 4 años (9%), sin embargo, la mayor incidencia de casos se da en mayores de 80 años. Los principales desafíos de esta enfermedad son el abordaje multidisciplinario en la gestión del manejo del vector, la evaluación de las causas de esta alta letalidad y la necesidad de una vacuna de uso poblacional.
During the summer of 2022 and 2023, the largest Chikungunya epidemic occurred in Paraguay, and one of the largest reported in the region. It was centralized in the metropolitan area of Asunción in a first stage, but it expanded to the rest of the country during the first months of 2023. This work has the objective of describing the epidemic epidemiologically and clinically from its beginning in epidemiological week 40 of 2022 to week 20 of 2023. Methodology: it is a descriptive study that uses the public data available on the page of the General Directorate of Health Surveillance. 86,761 cases were confirmed, 58% female, 8,227 hospital admissions, and 248 deaths. The global lethality is 2.8 per thousand confirmed cases. The most affected age groups correspond to the 0 to 4-year-old group (9%), however, the highest incidence of cases occurs in people over 80 years of age. The main challenges of this disease are the multidisciplinary approach in the management of the vector, the evaluation of the causes of this high lethality and the need for a vaccine for population use.
Subject(s)
Chikungunya Fever/epidemiologyABSTRACT
Durante el verano del 2022 y 2023 ocurrió la mayor epidemia de Chikungunya en Paraguay, y una de las más grandes reportadas en la región. Estuvo centralizada en el área metropolitana de Asunción en una primera etapa, pero se expandió al resto del país durante los primeros meses del 2023. Este trabajo tiene el objetivo de describir epidemiológica y clínicamente la epidemia desde su inicio en la semana epidemiológica 40 del 2022 hasta la semana 20 del 2023. Metodología: es un estudio descriptivo que utiliza los datos públicos disponibles en la página de la Dirección General de Vigilancia de la Salud. Fueron confirmados 86.761 casos, 58% femenino, 8227 ingresos hospitalarios y 248 fallecidos. La letalidad global es de 2.8 por mil casos confirmados. Los grupos etarios más afectados corresponden a la franja de 0 a 4 años (9%), sin embargo, la mayor incidencia de casos se da en mayores de 80 años. Los principales desafíos de esta enfermedad son el abordaje multidisciplinario en la gestión del manejo del vector, la evaluación de las causas de esta alta letalidad y la necesidad de una vacuna de uso poblacional.
During the summer of 2022 and 2023, the largest Chikungunya epidemic occurred in Paraguay, and one of the largest reported in the region. It was centralized in the metropolitan area of Asunción in a first stage, but it expanded to the rest of the country during the first months of 2023. This work has the objective of describing the epidemic epidemiologically and clinically from its beginning in epidemiological week 40 of 2022 to week 20 of 2023. Methodology: it is a descriptive study that uses the public data available on the page of the General Directorate of Health Surveillance. 86,761 cases were confirmed, 58% female, 8,227 hospital admissions, and 248 deaths. The global lethality is 2.8 per thousand confirmed cases. The most affected age groups correspond to the 0 to 4-year-old group (9%), however, the highest incidence of cases occurs in people over 80 years of age. The main challenges of this disease are the multidisciplinary approach in the management of the vector, the evaluation of the causes of this high lethality and the need for a vaccine for population use.
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INTRODUCCIÓN: La Neumonía por Síndrome Respiratorio Agudo Severo Coronavirus 2, es un problema de Salud Pública, por su alta tasa de mortalidad en la primera ola de la pandemia. OBJETIVO: Determinar los factores de riesgo asociados a la Neumonía por Síndrome Respiratorio Agudo Severo Coronavirus 2 en pacientes fallecidos internados en el área Covid y Unidad de Terapia Intensiva del Hospital Municipal Boliviano Holandés, Municipio El Alto, en los meses de marzo a diciembre 2020. MATERIAL Y MÉTODOS: Estudio observacional analítico de casos y controles, los casos 25 fueron pacientes fallecidos de neumonía por SARS-CoV-2 durante la estadía hospitalaria y los controles 75 pacientes no fallecidos por la enfermedad. La fuente de información fue el expediente clínico, ficha de notificación epidemiológica y certificado médico único de defunción. Se clasificó las causas de fallecimiento según el Código internacional de enfermedades CIE 10. RESULTADOS: Se obtuvo información de 25 casos y 75 controles, relación 1:3. Pacientes fallecidos del sexo masculino 72% con p=0.040 (OR 2.77 IC 95% 1.042 - 7.449); La edad de 60 años con p=0.000 (OR 4.12 IC95% 1.596 - 10.664); lugar de residencia urbano 88%; el periodo infeccioso fue de 9.68 días (IC95%7.83-11.52), tiempo de internación 6.60 días p=0.010 (OR 4.03 IC95% 1.446 - 11.231); las Enfermedades Crónicas no Transmisibles 80% con p=0.040 (OR 2.98 IC95% 1.009 - 8.779); los pacientes internados en el área COVID tuvo una mortalidad de 68% con p=0.010 (OR 0.25 IC95% 0.083 - 0.774) y recibieron tratamiento farmacológico 72%. CONCLUSIÓN: El sexo masculino, mayor de 60 años y las enfermedades Crónicas no Transmisibles son un factor de riesgo para altas tasas de letalidad, resultados respaldados según Serra Valdés1.
INTRODUCTION: Pneumonia due to Severe Acute Respiratory Syndrome Coronavirus 2 is a Public Health problem, due to its high mortality rate in the first wave of the pandemic. OBJECTIVE: To determine the risk factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 pneumonia in deceased patients hospitalized in the Covid area and Intensive Care Unit of the Bolivian Dutch Municipal Hospital, El Alto Municipality, from March to December 2020. MATERIAL AND METHODS: Analytical observational study of cases and controls, 25 cases were patients who died of SARS-CoV-2 pneumonia during their hospital permanence, and 75 controls were patients who did not die from the disease. The source of information was the clinical record. The method was documentary analysis, instruments were clinical histories, epidemiological notification sheet and official medical death certificate. The causes of death were classified according to the International Code of Diseases CIE 10. RESULTS: Information was obtained from 25 cases and 75 controls, ratio 1:3. 72% male patients who died with p=0.040 (OR 2.77 95% CI 1.042 - 7.449); The 60 years old with p=0.000 (OR 4.12 IC95% 1.596 - 10.664); urban area of residence 88%; the infectious period was 9.68 days (95%CI 7.83-11.52), hospitalization time 6.60 days p=0.010 (OR 4.03 95%CI 1.446 - 11.231); Chronic Noncommunicable Diseases of 80% with p=0.040 (OR 2.98 IC95% 1.009 - 8.779); The patients hospitalized in the COVID area had a mortality of 68% with p=0.010 (OR 0.25 IC95% 0.083 - 0.774) and 72% received pharmacological treatment. CONCLUSION: The male, over 60 years old and Chronic Non-Communicable Diseases are a risk factor for high-risk rates in high mortality rates, results are supported by Serra Valdés1.
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Male , Middle AgedABSTRACT
Background: Vaccines against the COVID-19 pandemic were introduced in late 2020. The present study has been conducted to study the serious Adverse Events Following Immunization (AEFIs) reported for COVID-19 vaccines from India. Methods: Secondary data analysis of the causality assessment reports for the 1112 serious AEFIs published by the Ministry of Health & Family Welfare, Government of India, was conducted. For the current analysis, all the reports published till 29.03.2022 were included. The primary outcome variables analyzed were the consistent causal association and the thromboembolic events. Results: The majority of the serious AEFIs assessed were either coincidental (578, 52%) or vaccine product related (218, 19.6%). All the serious AEFIs were reported among the Covishield (992, 89.2%) and COVAXIN (120, 10.8%) vaccines. Among these, 401 (36.1%) were deaths, and 711 (63.9%) were hospitalized and recovered. On adjusted analysis, females, the younger age group and non-fatal AEFIs showed a statistically significant consistent causal association with COVID-19 vaccination. Thromboembolic events were reported among 209 (18.8%) of the analyzed participants, with a significant association with higher age and case fatality rate. Conclusion: Deaths reported under serious AEFIs were found to have a relatively lower consistent causal relationship with the COVID-19 vaccines than the recovered hospitalizations in India. No consistent causal association was found between the thromboembolic events and the type of COVID-19 vaccine administered in India
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Post-independence, we made significant strides in childhood survival. However, there is an abysmal improvement in survival due to birth defects. Globally, India contributes the largest proportion of under-5 deaths, overall as well as due to birth defects. Congenital heart disease (CHD) is the single most common cause of birth-defect related deaths, and is the 7th most common cause of infant deaths. Scarcity of pediatric cardiac care professionals and pediatric cardiac centers has led to a huge demand-supply gap. Understanding the burden of CHD and taking imperative steps at primary, secondary and tertiary levels are essential during Amrit Kaal (2022-2047). Coverage of management of CHD under Janani Shishu Suraksha Karyakram, Rashtriya Bal Suraksha Karyakram and Ayushman Bharat programs offers a huge promise, as shown by the experience from Hridayam program in Kerala.
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Introduction: Epidemiological data related to maternal mortality is valuable in each setup to design interventional programs to reduce the ratio favorably. This study was done to evaluate the maternal mortality rate in our hospital GGH GUNTUR from January 2020 to December 2021, to assess the epidemiological aspects and causes of maternal mortality, and to suggest recommendations for improvement. Objectives: 1. To estimate the maternal mortality rate in GGH Guntur 2. To identify the causes associated with maternal mortality 3. To identify epidemiological risk factors for maternal mortality 4. To recommend ideas for reducing MMR to prevent maternal deaths. Methods: This is a 2-year retrospective study conducted in our hospital, GGH Guntur, Andhra Pradesh. All data presented were collected from hospital records and the causes were assessed, some of the epidemiological risk factors were identified, and maternal mortality rates were calculated. A total of 165 maternal deaths occurred. Most maternal deathsResults: occurred in the age group of 20–24 years, primi women (53.33%), women from rural areas (75.15%), and unbooked patients (95.15%). Direct causes accounted for 52.27% of maternal deaths, 28.48% of maternal deaths were due to indirect causes and 17.57% of maternal deaths were due to non-obstetric causes ( 89.65 % were due to covid-19) Conclusion: Better reporting of maternal deaths and implementation of evidence-based, focused strategies, along with effective monitoring of maternal health, emphasizes the need for regulation of the private sector and encourages further public-private partnerships and policies, as well as a robust political will and enhanced management capacity for improving maternal health, particularly in an unprecedented health crisis such as Covid-19. As a considerable number of the recorded deaths are preventable, there is substantial room for advancement.
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Resumo No cenário de calamidade assistido durante a pandemia de Covid-19, o ato de definir a causa básica de um óbito não foi trivial e o aumento da utilização dos códigos garbage (códigos mal definidos ou pouco específicos) traz preocupação em relação à qualidade da informação sobre as causas de morte nos estados do Brasil. Constatou-se um aumento significativo do número de óbitos no período pandêmico no estado da Paraíba, localizado na região Nordeste do Brasil, situação que se assemelhou ao contexto nacional. Em 2020 ocorreram 31.107 óbitos na Paraíba, enquanto no período de 2015 a 2019 foi identificada uma média de 27.000 óbitos. O objetivo do presente estudo é identificar e mensurar o excesso de óbitos classificados com códigos garbage em 2020, no estado da Paraíba, durante a pandemia de Covid-19. As séries temporais de óbitos foram obtidas do Painel de Monitoramento da Mortalidade por Causas Básicas Inespecíficas ou Incompletas (garbage codes) do Ministério da Saúde, para todos os meses de 2015 a 2020. Foram calculadas as projeções de óbitos totais e dos óbitos por códigos garbage (CG). O cálculo do excesso da proporção de óbitos classificados por códigos garbage no estado da Paraíba, em 2020, resultou em 8,58%, destacando-se o mês de junho com o maior valor (19,42%). Espera-se contribuir para avanços no conhecimento da realidade da qualidade da informação da notificação dos óbitos em uma área do país que almeja avanços nesse sentido e evidenciar a necessidade da investigação em outras localidades do Brasil.
Abstract In the disaster scenario witnessed during the pandemic caused by COVID-19, the act of defining the underlying cause of a death was no trivial matter and the increased use of Garbage Codes (poorly defined or not very specific codes) raises concerns regarding the quality of the information on causes of death in the states of Brazil. There was a significant increase in the number of deaths during the pandemic in the state of Paraíba, located in the Northeast region of Brazil, a situation similar to the national context. There were 31,107 deaths in 2020 in Paraíba, while an average of 27,000 deaths were identified for the period 2015 to 2019. Our goal was to identify and measure the excess of deaths classified with Garbage Codes in the COVID-19 pandemic in the geographic space of the state of Paraíba in 2020. The time series of deaths were obtained from the Mortality Monitoring Panel for Unspecific or Incomplete Basic Causes (Garbage Codes) of the Ministry of Health, for all months of the years 2015 to 2020. Projections of total deaths and deaths by Garbage Codes (GC) were calculated. The calculation of the excess proportion of deaths classified by Garbage Codes in the state of Paraíba resulted in 8.58%, highlighting the month of June 2020, which reached the maximum value equal to 19.42%. We expect to contribute to advance knowledge regarding the current reality of quality information on death notifications in an area of the country that seeks to make progress in this direction and to highlight the need for research in other locations in Brazil.
Resumen En el escenario de desastre que se vivió durante la pandemia de COVID-19, definir la causa subyacente de una muerte no fue baladí y el aumento del uso de códigos garbage (códigos mal definidos o poco específicos) genera preocupaciones acerca la calidad de la información sobre las causas de muerte en los estados de Brasil. En cuanto al aumento del número de muertes en el período de la pandemia en el estado de Paraíba, en la región Nordeste de Brasil, la situación fue similar al contexto nacional: 31.107 muertes en 2020, mientras que durante el período 2015-2019 el promedio fue de 27.000 muertes. El objetivo de este trabajo fue identificar y medir el exceso de muertes clasificadas con códigos Garbage en la pandemia de COVID-19 en el estado de Paraíba en 2020. Las series temporales de defunciones se obtuvieron del Panel de Seguimiento de Mortalidad por Causas Básicas Inespecíficas o Incompletas del Ministerio de Salud, para todos los meses de 2015 a 2020. Se calcularon proyecciones de muertes totales y muertes por códigos basura, para los que el cálculo de la proporción de exceso de muertes resultó en 8,58 %, con un valor de 19,42 % durante junio. Se espera contribuir a la calidad de la información sobre las notificaciones de muerte en un área del país que busca avances en esa dirección y resaltar la necesidad de investigaciones en otras localidades de Brasil.
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Resumo A expansão do uso de máquinas no campo tem promovido alterações no mundo do trabalho canavieiro. Frente a este cenário, lança-se a questão: Como se comportam os acidentes de trabalho e as mortes na realidade mecanizada dos canaviais brasileiros? Predominantemente quantitativa, a investigação que subsidia este texto se vale de dados secundários levantados junto à Plataforma Smartlab e a bases oficiais do governo ligadas ao mercado de trabalho formal (RAIS). Os resultados indicam que o conjunto de atividades agrícolas (manuais e mecanizadas) experimentou queda na incidência de acidentes de trabalho, mas não apresentou redução da taxa de mortes relacionadas ao trabalho. Como resultado, a letalidade foi ampliada no período demonstrando a preservação da superexploração dos trabalhadores. Espera-se que este texto possa lançar luz sobre os desdobramentos gerados pelo processo de mecanização agrícola, no que diz respeito a saúde e segurança dos canavieiros.
Abstract The expansion of the use of machines in the field has promoted changes in the world of sugarcane work. Faced with this scenario, the question arises: How do work accidents and deaths behave in the mechanized reality of Brazilian sugarcane plantations? Predominantly quantitative, the research that supports this text uses secondary data collected from the Smartlab Platform and official government databases, linked to the formal labor market (RAIS). The results indicate that the set of agricultural activities (manual and mechanized) experienced a decrease in the incidence of work accidents, but did not show a reduction in the rate of work-related deaths. As a result, lethality increased in the period, demonstrating the preservation of the overexploitation of workers. This text is expected to shed light on the consequences generated by the agricultural mechanization process regarding the health and safety of sugarcane workers.
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ABSTRACT Objective: To describe the impact of the Koala project (Actively Controlling Target Oxygen) on clinical outcomes in patients born with less than 36 weeks of gestation, in two maternity hospitals, comparing before and after the strategy implementation. Methods: This is an intervention study with 100 preterm infants with gestational age ≤36 weeks, who used oxygen in two maternity hospitals between January 2020 and August 2021. One of the hospitals was a private institution and the other was philanthropic. The goal for the target oxygen saturation with this project was 91-95%. Comparisons between the two stages (before and after the implementation of the project) were made evaluating the outcomes of retinopathy of prematurity, bronchopulmonary dysplasia, necrotizing enterocolitis, and deaths. The continuous variables were described using mean, median, standard deviation and interquartile interval. The significance level adopted was 5% and the software used was R Core Team 2021 (version 4.1.0). Results: After oxygen control use according to the Koala protocol, there was a significant reduction in the cases of retinopathy of prematurity (p<0.001) and bronchopulmonary dysplasia (p<0.001). There were no deaths in the second stage, and there was a non-significant increase in the absolute number of necrotizing enterocolitis cases. Conclusions: The Koala project seems to be an effective and feasible strategy to reduce adverse situations in the management of premature children, but research with a greater sample is needed.
RESUMO Objetivo: Descrever o impacto do projeto Coala (Controle Ativo de Oxigênio Alvo) nos desfechos clínicos em pacientes nascidos com menos de 36 semanas de gestação, em duas maternidades, comparando antes e depois da implementação da estratégia. Métodos: Trata-se de um estudo de intervenção com cem prematuros vivos, com idade gestacional ≤36 semanas, que utilizaram oxigênio em duas maternidades entre janeiro de 2020 e agosto de 2021. A meta para a saturação de oxigênio alvo com este projeto foi de 91-95%. Comparações entre as duas etapas (antes e depois da implantação do projeto) foram feitas avaliando os desfechos de retinopatia da prematuridade, displasia broncopulmonar, enterocolite necrosante e óbitos. As variáveis contínuas foram descritas por meio de média, mediana, desvio padrão e intervalo interquartil. O nível de significância adotado foi de 5% e o software empregado foi o R Core Team 2021 (versão 4.1.0). Resultados: Observou-se que, após o uso de controle de oxigênio segundo o protocolo Coala, houve redução significativa nos casos de retinopatia da prematuridade (p<0,001) e displasia broncopulmonar (p<0,001). Não houve óbitos na segunda etapa e houve aumento não significativo no número absoluto de casos de enterocolite necrosante. Conclusões: O projeto Coala parece ser uma estratégia eficaz e viável para reduzir situações adversas no manejo de crianças prematuras, mas pesquisas com amostras maiores são necessárias.
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ABSTRACT BACKGROUND: Multimorbidity can influence intensive care unit (ICU) admissions and deaths due to coronavirus disease (COVID-19). OBJECTIVE: To analyze the association between multimorbidity, ICU admissions, and deaths due to COVID-19 in Brazil. DESIGN AND SETTING: This cross-sectional study was conducted using data from patients with severe acute respiratory syndrome (SARS) due to COVID-19 recorded in the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe) in 2020. METHODS: Descriptive and stratified analyses of multimorbidity were performed based on sociodemographic, ventilatory support, and diagnostic variables. Poisson regression was used to estimate the prevalence ratios. RESULTS: We identified 671,593 cases of SARS caused by COVID-19, of which 62.4% had at least one morbidity. Multimorbidity was associated with male sex, age 60-70 and ≥ 80 years, brown and black skin color, elementary education and high school, ventilatory support, and altered radiologic exams. Moreover, all regions of the country and altered computed tomography due to COVID-19 or other diseases were associated with death; only the northeast region and higher education were associated with ICU admission. CONCLUSION: Our results showed an association between multimorbidity, ICU admission, and death in COVID-19 patients in Brazil.
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Neurosurgical patients are the most critical ICU admissions. While advancements in neurosurgical ICUs (NICU) have improved outcomes of care globally, ICU mortality remains a major clinical issue in developing nations. This study evaluates ICU mortalities of neurosurgical patients in a general ICU setting at the UNIOSUN Teaching Hospital, Osogbo, Nigeria. Method: Case records of neurosurgery patients who died in the ICU of UNIOSUN Teaching Hospital, Osogbo, South-Western, Nigeria from June 2012 to May 2022 were reviewed. Simple descriptive statistics of data on demographics, clinical diagnoses, management and outcome were done. Results: Mortality rate was 38.9% (84 of 216 admissions). Males were 67(79.8%) and the mean age was 41.5years (Range: 2-85years). The average duration of ICU stay was 3.5days (Range: 30minutes-20days). Most patients had severe traumatic brain injury (TBI) (62, 73.8%). This was followed by cerebrovascular diseases (12, 14.3%) and brain tumours (6, 7.1%). Two had brain abscess. One patient each had mixed subacute/chronic subdural haematoma and severe cervical spondylotic myelopathy. Of the 69 whose case files were found, 7(10.1%) had a diagnosis of brainstem death before eventual 'final' death after an average of 13.5 additional hours on mechanical life support. The identified secondary causes of death included raised ICP, sepsis, primary surgical haemorrhage, seizures, acute kidney injury, malignant hypertension, poor glycaemic control and aggressive blood pressure lowering. Only 1 patient had autopsy. Conclusion: Most ICU mortalities among neurosurgical patients were from severe TBI. The establishment of NICU is necessary to improve outcome of care of neurosurgical patients
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Humans , Neurosurgical Procedures , Intensive Care Units , Spinal Cord Diseases , Cerebrovascular Disorders , Sepsis , Hypertension, MalignantABSTRACT
Objective:To investigate the predictive value of systematic immune-inflammation index(SII) in severity and prognosis of the patients with acute pulmonary embolism(APE).Methods:By retrospective research methods, the clinical data of 120 APE patients from June 2020 to January 2022 in Hubei University of Medicine Affiliated Dongfeng General Hospital were analyzed. The pulmonary embolism-related deaths within 6 months was the end point events. The influence factors were explored by multivariate Logistic regression analysis, the predictive value of pulmonary embolism severity index (PESI) and SII on the end point events of patients were assessed by receiver operating characteristic(ROC) curve.Results:According to the pulmonary embolism-related deaths within 6 months as the end point events they were divided into the survival group (96 cases) and the death group (24 cases). The age, systolic blood pressure, heart rate, respiratory rate, incidence of congestive heart failure, level of B-type natriuretic peptide, PESI score, and SII in the death group were higher than those in the survival group: (66.00 ± 8.85) years vs. (61.21 ± 5.99) years, (129.83 ± 14.76) mmHg (1 mmHg = 0.133 kPa) vs. (122.77 ± 10.21) mmHg, (102.04 ± 9.43) beats/min vs. (92.54 ± 11.34) beats/min, (20.83 ± 2.37) beats/min vs. (19.72 ± 1.77) beats/min, 41.67%(10/24) vs. 14.58%(14/96), (211.67 ± 85.38) ng/L vs. (167.86 ± 71.88) ng/L, (110.17 ± 19.13) scores vs. (89.09 ± 12.63) scores, (1 068.58 ± 230.65) × 10 9/L vs. (784.22 ± 233.98)×10 9/L, there were statistical differences ( P<0.05). Multivariate Logistic regression analysis showed that age, heart rate, PESI score and SII were the independent risk factors of death related to pulmonary embolism in APE patients ( P<0.05). The results of ROC curve showed that the area under curve of PESI and SII for the prediction of pulmonary embolism related death was 0.816 and 0.791, respectively, there was no statistical difference ( P>0.05). According to the cut-off of SII (882.40 × 10 9/L), they also assigned to the SII<882.40 × 10 9/L group (61 cases) and the SII≥882.40 × 10 9/L group (59 cases), The results of Kaplan-Meier survival analysis showed that the 6-month survival rate in the SII<882.40 × 10 9/L group was higher than that in the SII≥882.40 × 10 9/L group, there was statistical difference ( P<0.05). Conclusions:SII can effectively evaluate the survival prognosis of acute pulmonary embolism patients, and it can be used as one of the indicators for evaluating the prognosis of patients.
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Sudden cardiac death(SCD)in the elderly is defined as a sudden accidental death in patients over 65 years of age within one hour of symptom onset or within 24 hours with no symptoms, possibly due to arrhythmia or abrupt hemodynamic changes.It is characterized by rapid onset, rapid progression, and high mortality.Sudden cardiac death in the elderly is the most serious clinical syndrome in elderly patients with heart disease.It accounts for more than 80% of all sudden death cases and is the cause of sudden death in the vast majority of elderly patients.Clinical methods for the detection of sudden cardiac death include mostly screening through family and personal history, physical examination, electrocardiogram analysis and echocardiography, but their drawbacks include lack specificity, low detection rates and relatively limited scenarios for their use.Genetic susceptibility is also responsible for sudden cardiac death.Genetic factors play an important role in the occurrence and development of sudden cardiac death.This review summarized the correlation between sudden death and genetic factors underlying different cardiovascular diseases, including the role of genetic polymorphisms in the occurrence of sudden cardiac death in older adults.
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@#Stigma due to an HIV diagnosis is a well-known phenomenon and is a major barrier to accessing care.1 Over the last forty years, HIV has been transformed from a fatal disease to a manageable one, thanks to the remarkable success of antiretroviral (ARV) medication.2 When people living with HIV (PLHIV) start ARV treatment early, their life expectancy is almost completely restored. Moreover, a suppressed viral load means that PLHIV are no longer able to infect other people.3 They can have children naturally without risk to their seronegative partner or their child. PLHIV nowadays are more likely to die with HIV, not of HIV. While a cure remains elusive, the successful global rollout of ARVs means that there is no good reason for a PLHIV to die of AIDS and its complications due to lack of access to proper treatment. The Philippine AIDS Law Republic Act 8504 and its successor, Republic Act 11116 explicitly states that the State should “ensure access to HIV and AIDS-related services by eliminating the climate of stigma and discrimination that surrounds the country’s HIV and AIDS situation, and the people directly and indirectly affected by it.” Unfortunately, despite this admonition, stigma remains a significant cause of delayed HIV testing and of not seeking treatment in our country. In this issue of the journal, Dr. De Los Santos and her colleagues examine the effect of healthcare facility stigma on PLHIV accessing care in the Philippines.4 They report that 81% of their Filipino PLHIV respondents experienced stigma, which is an unacceptably high number. They identify which facilities are more likely to be correlated with stigma and make suggestions on how to address this problem. This study is very timely and comes at a time when the Department of Health is shifting first line antiretrovirals to dolutegravir-based regimens.5 Dolutegravir-based treatment is associated with fewer side effects than efavirenz-based regimens and is much more durable against resistance.6 With an HIV transmitted-drug resistance rate of 11.7%, it is imperative that PLHIV are started on more durable regimens which they are less likely to discontinue.7 Properly addressing stigma means that more people will access care. Better regimens will ensure that people stay in care. This will go a long way towards minimizing the impact of HIV and AIDS on Filipino PLHIV. Stigma among PLHIV is a complicated subject matter. Aside from the stigma associated with diagnosis, there is also stigma associated with the mode of acquisition of the disease. The most-at-risk populations are highly stigmatized. Men who have sex with men, people who inject drugs, and female sex workers experience additional stigma on top of the stigma from an HIV diagnosis.8 Aside from societal stigma, PLHIV are also prone to self-stigma.9 This phenomenon occurs when PLHIV believe they no longer deserve to live since they contracted the disease from deviant or sinful behavior. High rates of depression are found among these self-stigma sufferers. This significantly impacts the entire HIV healthcare cascade, starting from early diagnosis, to accessing treatment, and staying in care. The finding that Public Rural Health Units are the most stigmatizing healthcare facilities is very concerning since these are usually the only facilities available to PLHIV in far-flung areas. This needs to be addressed with better sensitivity training as well as concrete guidelines on avoiding stigma. It is very troubling that facilities that are supposed to cater to vulnerable populations inadvertently make it difficult for them to access care.10 Unfortunately, even facilities in urban areas are not immune to discrimination and stigmatizing behavior. I recall the experience of one of my early PLHIV patients who developed and eventually succumbed to a disseminated fungal infection.11 He told me that he had tried getting tested several years earlier but he had a traumatic experience in the government health facility that he accessed. He made a wrong turn and entered a different clinic in that hospital and when he asked for an HIV test, people recoiled from him in horror. Because of that terrible experience, he put off getting his HIV test for years until he started developing the fungal infection that eventually killed him. Had he been started on proper treatment earlier, he could have been saved. For me, it wasn’t just the fungus that killed him but it was the delay in diagnosis and care as a direct result of stigma. Addressing HIV-related stigma in our country entails a whole-of-society and a whole-of-nation approach. Mental health services to address self-stigma and depression should be standard of care not just among confirmed PLHIV but among the most-at-risk populations. Proactive education of all members of society, especially healthcare workers in facilities that diagnose and care for PLHIV is essential for ensuring sustained linkage to care. Ensuring that the majority of the PLHIV population are properly diagnosed, enrolled in treatment hubs, and have suppressed viral loads will ultimately lead to fewer transmissions and less AIDS-related deaths.
Subject(s)
HIV , Acquired Immunodeficiency SyndromeABSTRACT
Introducción: En las últimas semanas de 2022 aparecen nuevas informaciones acerca del exceso de muertes durante la pandemia de COVID-19 en 2020 y 2021 en múltiples naciones. Objetivo: Comentar los aspectos de mayor interés en las últimas informaciones publicadas. Métodos: Análisis de documentos sobre COVID-19 publicados en 2020 y 2021 y síntesis de la información recopilada. Resultados: Un importante estudio de la OMS estima un exceso de muertes de 14,83 (13,23 ± 16,58) millones más de las esperadas en todo el mundo, durante 2020 y 2021. Estos estimados son más conservadores que los de otras instituciones que estimaron entre 16 y 18,2 millones. El informe de OMS estima que cuatro de cada cinco países con mayores excesos de muertes ocurren en estados de "medianos ingresos", con algunos de los peores 25 resultados en América Latina (Cuba no está incluida). No se documenta todavía lo ocurrido durante 2022 que ya termina. Conclusiones: En el futuro se debe mantener la vigilancia de la evolución de las cifras de mortalidad y la estructura por causas de muerte en las poblaciones.
Introduction: In the last weeks of 2022, new information appears about the excess deaths during the COVID-19 pandemic in 2020 and 2021 in multiple nations. Objective: To comment on the aspects of greatest interest in those cited documents. Methods: Analysis of documents on COVID-19 was conducted on those published in 2020 and 2021 and synthesis of the information collected. Results: A major WHO study estimates an excess of deaths of 14.83 (13.23 ± 16.58) million more than expected worldwide, during 2020 and 2021. These estimates are more conservative than those of other institutions that estimated between 16 and 18.2 million. The WHO report estimates that four out of five countries with the highest excess deaths occur in "middle-income" states, with some of the worst outcomes in Latin America. Cuba is not included. What happened during 2022, which is already ending, has not yet been documented. Conclusions: It is considered that monitoring of the evolution of mortality figures and the structure by causes of death in populations should be maintained in the future.
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Resumen Objetivo: Determinar la relación entre las categorías sociales en la incidencia de muerte materna en el periodo 2014-2019, en el estado de Nuevo León. Material y Métodos: Se realizó un análisis estadístico de las muertes maternas en el estado con la base de datos proporcionada por la Secretaría de Salud federal, filtrando la información de las categorías sociales de las mujeres que fallecieron por causas maternas. Posteriormente los datos obtenidos fueron procesados en el programa SPSS 22, realizando un análisis de estadística descriptiva, chi cuadrado y regresión logística. Resultados: Las categorías sociales, escolaridad, estado civil y edad resultan ser significativas para la probabilidad de morir por causa materna, las mujeres con alta escolaridad reducen el riesgo de morir en un 22.8%, las mujeres con escolaridad media reducen en un 50.8% la probabilidad de morir en comparación con las mujeres de escolaridad baja, por su parte las mujeres solteras reducen la probabilidad de morir por causa materna en un 79.5%, asimismo, las mujeres de 15 a 24 años tienen 105.3 veces más probabilidad de morir, mientras que las mujeres de 25 a 39 años tienen 35.4 veces más probabilidad de morir por causa materna, en relación con las mujeres de 40 a 55 años. Conclusión: La edad, la escolaridad, así como encontrarse en una relación de pareja aumentan significativamente la probabilidad de morir por causa materna, por lo que se puede concluir con el hecho de que las mujeres son violentadas por cuestiones de género, sin embargo, existen categorías sociales que hacen claras distinciones en el trato y atención en relación con su embarazo, parto y puerperio.
Abstract Objective: To determine the relation between social categories in the incidence of maternal death in 2014-2019 in the state of Nuevo León. Material and Methods: A statistical analysis of maternal deaths in the state with the database provided by the federal Ministry of Health, filtering the information of the social categories of women who died from maternal causes. Subsequently, the data obtained were processed in the SPSS 22 program, performing a descriptive statistical analysis, chi square and logistic regression. Results: Social categories, schooling, marital status and age turn out to be significant for the probability of dying from maternal causes, women with high schooling reduce the risk of dying by 22.8%, women with medium schooling reduce the probability by 50.8% of dying compared to women with a low education level, for their part, single women reduce the probability of dying from maternal causes by 79.5%, likewise, women aged 15 to 24 are 105.3 times more likely to die, while women aged 25 to 39 are 35.4 times more likely to die from maternal causes than women aged 40 to 55. Conclusion: Age, schooling, as well as being in a relationship significantly increase the probability of dying from maternal causes, so it can be concluded with the fact that women are violated due to gender issues, however, there are categories that make clear distinctions in the treatment and care in relation to their pregnancy, childbirth and puerperium.
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Anonymous sources are used by journalists when it is important to protect whistleblowers from repercussions. Healthcare is heavily influenced by vested interests which are often financial, but academic prestige and protection of guild interests also play a major role. If anonymous authorship is not allowed, many potential whistleblowers would prefer to keep quiet, even though their stepping forward would serve the public interest and might save many lives, particularly by reducing prescription drug deaths. This is especially important since drugs are the third leading cause of death in the Western world.
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The appearance of healthcare professionals and their interaction with patients has always been the scaffolding of the relationship between the caregiver and patient. The Covid-19 pandemic has challenged this with its need for masking and distancing. The duty bound frontline worker in the midst of the personal crisis brought about by this pandemic has undergone hitherto unknown experiences described here.
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Background: Injuries due to road traffic injuries (RTIs) depend upon various factors that include human, vehicle and environmental factors that plays a vital role before, during and after a fatal vehicular accident. Road traffic injuries involve high human suffering and monetary costs in terms of ultimately deaths, injuries and loss of potential income. Aims and Objective: The aims and objective of study was to study the incidence of death due to road traffic injuries, demographic profile including various contributary factors of victims and vehicles and to analyse the magnitude of deaths.Material & Methods:The present retrospective and cross sectional study was conducted in Forensic Medicine & Toxicology Department, Government Medical College, Amritsar. All the autopsies conducted on road traffic injuries victims during the period from Jan, 2016 to Dec, 2020 were studied. Results:Majority of cases taken up for study were males (80%) followed by females (20%), majority cases belonged to the age group of 21 -30 years (34.72%). The majority of cases (70.61 %)that met with road traffic injury happened at evening time period. Head injury was the cause of death in 42.45% cases followed by 33.88% cases having multiple injuries.Conclusions:Motorization though has enhanced the lives in this era but that has come up with some price. High priority is demanded towards the alarming rate of human loss due to RTIs. Awareness at every level including the strict formation of policies that would prevent such RTIs in future.